Scientific Research & Evidence
- The endospore-forming rhizobacterium Bacillus subtilis- the model system for Gram-positive organisms, is able to produce more than two dozen antibiotics with an amazing variety of structures. The produced anti-microbial active compounds include predominantly peptides that are either ribosomally synthesized and post-translationally modified (lantibiotics and lantibiotic-like peptides) or non-ribosomally generated, as well as a couple of non-peptidic compounds such as polyketides, an aminosugar, and a phospholipid.
- For many years most of the available evidence concerning genotypic variation among different B. subtilis isolates came from the assessment of phenotypic variation, principally strain-to-strain variation in the ability to make various antibiotics
- Bacillus subtilis is a spore forming, motile, rod-shaped, Gram-positive, facultative aerobe. It is mostly found in soil and vegetation with an optimal growth temperature from 25-35 degrees Celsius. B. subtilis has the ability to produce and secrete antibiotics.
- Lactobacillus rhamnosus GG (LGG) is one of the most widely used probiotic strains. Various health effects are well documented including the prevention and treatment of gastro-intestinal infections and diarrhea, and stimulation of immune responses that promote vaccination or even prevent certain allergic symptoms.
- Probiotics contain different types of micro-organisms such as yeast (saccharomyces boulardii) and bacteria (such as lactobacillus, bifidobacterium). Micro-organisms (flora) are naturally found in the stomach/intestines/vagina. Some conditions (such as antibiotic use, travel) can change the normal balance of bacteria/yeast. Probiotics are used to improve digestion and restore normal flora.
- Lactobacillus GG was first isolated in 1983 and is known to have a strong avidity for human intestinal cells and can survive acid and bile environments. It is considered one of the most studied probiotics, with research showing that it could alleviate rotavirus diarrhea in children, prevent atopic dermatitis protect against urinary tract infections and improve symptoms of irritable bowel syndrome LGG appears to be safe and effective in prolonging remission in UC patients.
- Lactobacillus casei, or L. casei. It’s one of many friendly bacteria that call your digestive system home. You probably also have some in your urinary and genital tracts. These helpful organisms are also known as probiotics. Unlike the harmful bacteria that make you sick, probiotics like L. casei are beneficial to your digestive system. Actually, your body depends on them. Without them, it’s much harder to digest food and absorb important nutrients.
- LcS contributed to weight loss while also improving the lipid metabolism in obese children via a significant increase in the faecal Bifidobacterium numbers and the acetic acid concentration.
- Some L. casei strains are considered to be probiotic, and may be effective in the alleviation of gastrointestinal pathogenic bacterial diseases. According to World Health Organization, those properties have to be demonstrated on each specific strain—including human clinical studies—to be valid. L. casei has been combined with other probiotic strains of bacteria in randomized trials studying its effects in preventing antibiotic-associated diarrhea
- These strains were reported to posses the down regulation of the risk of cardiovascular diseases (Ahren et al., 2014), produce pro-inflammatory cytokines in the intestinal epithelial cells (Murofushi et al., 2015), produce varied concentrations of exopolysaccharide with anticancer property (Wang et al., 2014), reduce kidney stones (Sasikumar et al., 2014), enhance splenocytes in dendritic cells (Ku et al., 2014) and reduce the cholesterol level in the adipose tissue (Li et al., 2014. Recently, Ilavenil et al. (2015) claimed that the phenyl lactic acid recovered from L. plantarum promotes adipogenic activity in 3T3-L1. Interestingly, L. plantarum significantly induces mucosal, humoral and cellular immune responses (Shi et al., 2014) and protects against symptoms of irritable bowel syndrome (Stevenson et al., 2014). It inhibited the production of pro-inflammatory cytokines such as NF-κB and suppresses atherosclerotic plaque inflammation (Kim et al., 2013) and induces the enhanced production of cytokines in the human intestine (Salah et al., 2012). On the other hand, L. plantarum strains are mainly involved in the T-cell differentiation thereby improving immune responses toward antigens (Vissers et al., 2010) and preventing dermatitis by increment of type 1 helper T cell activation and regulatory T cell activation (Won et al., 2012).
- L. plantarum is a bacterium that is very versatile and can adapt to various environmental conditions since it can ferment different types of carbohydrates and sugars. Specifically, it is able to withstand and grow in the harsh conditions of the gastrointestinal tract. Because of this, it can be used as a probiotic to benefit human health. A variety of strains or recombinants of L. plantarum can aid in restoring the homeostasis of the flora in the intestines, limit the amount of pathogenic bacteria, and could be potentially used as a vehicles for vaccines. However, not all the mechanisms for vaccinations with L. plantarum are known. As a result, many research groups are trying to determine possible mechanisms. Within the next few years, it is expected that more developments will be made to utilize the probiotic property of L. plantarum to benefit human health.
- Lactobacillus plantarum is a helpful guest probiotic that fiercely attacks pathogenic, bad bacteria in our bodies. By killing the bad guys, it helps our own native bacteria grow stronger...and helps us be more resistant to future invasions of pathogens.
- Due to the fact that Bifidobacterium longum is nonpathogenic, it is able to be used in various research studies in the body ... Bifidobacteria have also been seen to help in cancer prevention and therapy. Enzyme/prodrug therapy is a treatment for cancer that is currently being researched.
- Helps fight infections, might help in the treatment of anxiety, stimulates immune system, reduces obesity-related hepatitis, earlier research evaluated using the B. longum as a delivery mechanism for chemotherapy for colon cancers.
- Bifidobacteria are used for many conditions affecting the intestines, including preventing diarrhea in infants and children; as well as traveler's diarrhea in adults. Some people take bifidobacteria to restore "good bacteria" in the gut that have been killed or removed by diarrhea, radiation, chemotherapy, antibiotics, or other causes. Bifidobacteria are also used to treat a bowel disease called ulcerative colitis, as well as a condition called pouchitis, which sometimes develops after surgery for ulcerative colitis. Some people use Bifidobacteria to prevent a particular bowel infection called necrotizing enterocolitis in newborns.
- They have been used to treat a number of conditions including constipation, diarrhea, irritable bowel syndrome and even the cold and flu.
- The composition of the gut microbiota differs between lean and obese subjects and is recognized as a therapeutic target of obesity. In a meta-analysis of randomized controlled trials to examine the effects of probiotic supplementation on the body composition in overweight (BMI 25–29.9 kg/m2) and obese (BMI ≥30 kg/m2) subjects, five studies reported changes in percent body fat, and the pooled estimate showed that percent body fat was significantly lower in the intervention groups (−0.60%) than in the control groups, with low heterogeneity between the studies.
- B. breve also helps to boost the immune system, helping to alleviate the symptoms of allergic rhinitis. It appears that regular supplementation of B. breve can help to suppress the body’s immune response, thus dampening allergic reactions.
- L. acidophilus has been used to control certain types of diarrhea. It may be helpful for diarrhea due to oral antibiotics. These medicines kill the normal flora of the intestine. Consuming L. acidophilus helps put good bacteria into the intestines. This often stops diarrhea. It may also help treat vaginal yeast infections.
- L. acidophilus is a probiotic bacteria that naturally occurs in the human gut and other parts of the body. This bacteria helps the digestive system break down sugars, such as lactose, into lactic acid.
- Lactobacillus acidophilus has been used in alternative medicine as a possibly effective aid (in children or adults) in preventing diarrhea caused by antibiotics, travel, chemotherapy, or hospitalization. Lactobacillus acidophilus is also possibly effective in treating irritable bowel syndrome, bacterial vaginal infection, colic in babies, lung infections in children, skin problems in children who are allergic to milk, and other conditions. Lactobacillus acidophilus has also been used to treat lactose intolerance, Crohn's disease, overgrowth of bacteria in the intestines, or vaginal yeast infections caused by antibiotics. However, research has shown that lactobacillus acidophilus may not be effective in treating these conditions.